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Hiroyuki Arai Selected Research

Cetuximab (Erbitux)

4/2024Switching from FOLFIRI plus cetuximab to FOLFIRI plus bevacizumab based on early tumor shrinkage in RAS wild-type metastatic colorectal cancer: A phase II trial (HYBRID).
1/2022Germline Polymorphisms in Genes Involved in the Antioxidant System Predict the Efficacy of Cetuximab in Metastatic Colorectal Cancer Patients Enrolled in FIRE-3 Trial.
1/2022Genetic variants involved in the cGAS-STING pathway predict outcome in patients with metastatic colorectal cancer: Data from FIRE-3 and TRIBE trials.
1/2021Germ line polymorphisms of genes involved in pluripotency transcription factors predict efficacy of cetuximab in metastatic colorectal cancer.
1/2020Phase I study of the anti-heparin-binding epidermal growth factor-like growth factor antibody U3-1565 with cetuximab in patients with cetuximab- or panitumumab-resistant metastatic colorectal cancer.

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Hiroyuki Arai Research Topics

Disease

74Alzheimer Disease (Alzheimer's Disease)
04/2024 - 05/2002
40Neoplasms (Cancer)
04/2024 - 07/2002
30Dementia (Dementias)
10/2019 - 08/2002
26Cognitive Dysfunction
10/2022 - 03/2002
21Colorectal Neoplasms (Colorectal Cancer)
04/2024 - 10/2004
16Inflammation (Inflammations)
04/2024 - 06/2002
13Stomach Neoplasms (Stomach Cancer)
04/2024 - 12/2004
12Amyloid Plaque
09/2015 - 03/2004
10Neoplasm Metastasis (Metastasis)
11/2021 - 07/2007
9Bites and Stings (Sting)
01/2024 - 01/2016
7Pneumonia (Pneumonitis)
01/2021 - 09/2006
7Cough
06/2011 - 07/2003
7Aspiration Pneumonia
01/2010 - 07/2003
6Neurodegenerative Diseases (Neurodegenerative Disease)
03/2023 - 07/2006
6Infections
02/2023 - 11/2009
6Vitamin E Deficiency
11/2021 - 04/2010
6Peritonitis
12/2014 - 08/2009
6Myopia
02/2014 - 11/2004
5Cataract (Cataracts)
08/2021 - 05/2005
5Parkinson Disease (Parkinson's Disease)
08/2016 - 08/2003
5Stroke (Strokes)
10/2009 - 01/2005
4Seasonal Allergic Rhinitis (Hay Fever)
12/2023 - 01/2020
4Necrosis
01/2021 - 11/2005
4Astigmatism
03/2017 - 11/2004
4Prostatic Neoplasms (Prostate Cancer)
10/2015 - 07/2004
3Diarrhea
04/2024 - 06/2015
3Hypercholesterolemia
01/2023 - 08/2004
3Atherosclerosis
01/2023 - 07/2004
3Body Weight (Weight, Body)
01/2022 - 12/2002
3Ataxia with vitamin E deficiency
11/2021 - 10/2003
3Gliosis
01/2021 - 01/2018
3Asthma (Bronchial Asthma)
01/2021 - 04/2012
3Disease Progression
01/2020 - 11/2009
3Hypersensitivity (Allergy)
11/2017 - 10/2007

Drug/Important Bio-Agent (IBA)

30Amyloid (Amyloid Fibrils)IBA
01/2024 - 11/2004
30Proteins (Proteins, Gene)FDA Link
11/2023 - 10/2003
27Biomarkers (Surrogate Marker)IBA
03/2024 - 05/2002
19LipidsIBA
01/2024 - 10/2003
15lysophosphatidic acidIBA
02/2008 - 07/2002
12Phospholipids (Phosphatides)FDA LinkGeneric
11/2023 - 05/2002
12tau Proteins (tau Protein)IBA
05/2023 - 08/2002
10DNA (Deoxyribonucleic Acid)IBA
03/2024 - 11/2009
10Amyloid beta-PeptidesIBA
05/2023 - 12/2003
10EnzymesIBA
11/2020 - 05/2006
8Phosphotransferases (Kinase)IBA
03/2024 - 01/2013
8alkylglycerophosphoethanolamine phosphodiesteraseIBA
02/2008 - 07/2002
7InterferonsIBA
01/2024 - 01/2016
7Fatty Acids (Saturated Fatty Acids)IBA
11/2023 - 04/2012
7Vitamin EFDA LinkGeneric
01/2022 - 11/2009
7BenzoxazolesIBA
11/2014 - 03/2004
72- (2- (2- dimethylaminothiazol- 5- yl)ethenyl)- 6- (2- (fluoro)ethoxy)benzoxazoleIBA
08/2013 - 04/2007
6Interferon Type IIBA
01/2024 - 01/2016
6thiamine triphosphorate (TTP)IBA
01/2022 - 11/2010
6Tocopherols (Tocopherol)IBA
01/2022 - 11/2010
6alpha-tocopherol transfer proteinIBA
05/2010 - 10/2003
5Cetuximab (Erbitux)FDA Link
04/2024 - 01/2020
5AntigensIBA
12/2023 - 02/2008
5AntioxidantsIBA
12/2022 - 10/2003
5THK5351IBA
01/2021 - 02/2016
5ZymosanIBA
12/2014 - 02/2011
5alpha-TocopherolFDA Link
05/2010 - 10/2003
5Messenger RNA (mRNA)IBA
09/2007 - 01/2004
5Lysophosphatidic Acid ReceptorsIBA
01/2006 - 01/2004
4Cholinesterase Inhibitors (Anticholinesterases)IBA
04/2024 - 12/2005
4Bevacizumab (Avastin)FDA Link
04/2024 - 11/2020
4Immune Checkpoint InhibitorsIBA
03/2024 - 01/2019
4CholesterolIBA
01/2024 - 08/2006
4Peptides (Polypeptides)IBA
02/2023 - 11/2012
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2022 - 05/2006
4ApolipoproteinsIBA
01/2018 - 05/2004
4Apolipoproteins E (ApoE)IBA
01/2018 - 07/2006
4Yi-Gan SanIBA
02/2017 - 02/2005
4Choline (Choline Chloride)IBA
02/2016 - 07/2007
4Lysophosphatidylcholines (Lysophosphatidylcholine)IBA
11/2007 - 04/2004
3CytokinesIBA
04/2024 - 08/2009
3Cholinergic Agents (Cholinergics)IBA
04/2024 - 01/2003
3Calcibiotic Root Canal SealerIBA
03/2024 - 01/2022
3LigandsIBA
01/2024 - 11/2009
3Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2024 - 07/2004
3cyclic guanosine monophosphate-adenosine monophosphateIBA
02/2023 - 01/2021
3Serine (L-Serine)FDA Link
02/2023 - 01/2003
3Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2022 - 01/2020
3Irinotecan (Camptosar)FDA LinkGeneric
01/2022 - 01/2020
3Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
01/2022 - 11/2013
3Transferrin (beta 2 Transferrin)IBA
09/2021 - 01/2008
3AcyltransferasesIBA
01/2021 - 11/2012
3Monoamine Oxidase (MAO)IBA
01/2021 - 08/2018
3Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA
01/2021 - 01/2013
3EicosanoidsIBA
11/2017 - 04/2005
3SynucleinsIBA
08/2016 - 11/2009
3Carrier Proteins (Binding Protein)IBA
01/2014 - 07/2006
3Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
01/2014 - 01/2013
3Citric Acid (Citrate)FDA LinkGeneric
06/2011 - 09/2003

Therapy/Procedure

37Therapeutics
04/2024 - 07/2002
16Drug Therapy (Chemotherapy)
12/2023 - 10/2017
8Activities of Daily Living (ADL)
01/2023 - 07/2003
7Laser In Situ Keratomileusis (LASIK)
02/2014 - 11/2004
4Phakic Intraocular Lenses
08/2021 - 05/2005
3Immunotherapy
03/2024 - 12/2020
3Intravenous Injections
11/2014 - 03/2004